Article
Lack of association between nuclear factor erythroid-derived 2-like 2 promoter gene polymorphisms and oxidative stress biomarkers in amyotrophic lateral sclerosis patients.
Oxidative medicine and cellular longevity - 1 Jan 2014
LoGerfo Annalisa, Chico Lucia, Borgia Loredana, Petrozzi Lucia, Rocchi Anna, D'Amelio Antonia, Carlesi Cecilia, Caldarazzo Ienco Elena, Mancuso Michelangelo, Siciliano Gabriele
Abstract excerpt
Oxidative stress involvement has been strongly hypothesized among the possible pathogenic mechanisms of motor neuron degeneration in amyotrophic lateral sclerosis (ALS). The intracellular redox balance is finely modulated by numerous complex mechanisms critical for cellular functions, among which the nuclear factor erythroid-derived 2-like 2 (NFE2L2/Nrf2) pathways. We genotyped, in a cohort of ALS patients (n =...
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