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Mitochondrial tRNAGly A10055G mutation contributes to non-syndromic hearing loss: a study of three Han Chinese pedigrees.

Mitochondrial DNA. Part A, DNA mapping, sequencing, and analysis - 1 Jan 2026

Chen Xiao-Xiang, He Xiu-Mei, Li Yun, Jiang Bin, Zhou Xiang, Ding Yu

Abstract excerpt

Mutations in mitochondrial tRNA (mt-tRNA) genes are associated with non-syndromic hearing loss (NSHL), though their detailed molecular mechanisms and pathogenic potential remain unclear. In this study, we reported three Han Chinese pedigrees exhibiting maternally transmitted NSHL. Mitochondrial genomes from probands were sequenced and compared to revised Cambridge reference sequence (rCRS), followed by...

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Source

Identifiers

PMID: 42489722
DOI: 10.1080/24701394.2026.2706011

Genes

GJB2
GJB3
GJB6
TRMU

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 17 Oct 2026.

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