Article
CRISPR/Cas9-Mediated Disruption of ZNF543 Gene: An Approach Toward Discovering Its Relation to TRIM28 Gene in Parkinson's Disease.
Molecular biotechnology - 1 Feb 2023
Hashemabadi Mohammad, Sasan Hosseinali, Amandadi Mojdeh, Esmaeilzadeh-Salestani Keyvan, Esmaeili-Mahani Saeed, Ravan Hadi
Abstract excerpt
Genetic studies of familial forms of Parkinson's disease (PD) have shown that the ZNF543 gene is a candidate gene that operates relevant to this disease. However, until now, there is no evidence for ZNF543 gene function in PD, and mechanisms resulting from its mutation have not been elucidated. Given the same genetic location of the ZNF543 gene with TRIM28 and their effects on PD pathogenesis, we surmised that...
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