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Article

Parkinson's Disease-Associated Mutant LRRK2-Mediated Inhibition of miRNA Activity is Antagonized by TRIM32.

Molecular neurobiology - 1 Apr 2018

Gonzalez-Cano Laura, Menzl Ingeborg, Tisserand Johan, Nicklas Sarah, Schwamborn Jens C

Abstract excerpt

Parkinson's disease (PD) is the second most common neurodegenerative disorder. Accumulating evidences suggest that PD might have a strong neurodevelopmental component. Among the genetic cases, mutations in the leucine-rich repeat kinase 2 (LRRK2) are well known to be disease causing. Although the molecular mechanism of the pathogenic LRRK2 function is not fully clear, inhibition of microRNA (miRNA) activity has...

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Source

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Identifiers

PMID: 28508149
DOI: 10.1007/s12035-017-0570-y
PMCID: PMC5842508

Genes

TRIM32

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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