CRISPR/Cas9 Mediated-Disruption of ZNF543 Gene: An Approach Towards Discovering Its Relation to TRIM28 Gene in Parkinson's Disease

Abstract excerpt

<title>Abstract</title> <p>Genetic studies of familial forms of Parkinson’s disease (PD) have shown that the <italic>ZNF543</italic> gene is a candidate gene that operates relevant to this disease. However, until now there is no evidence for <italic>ZNF543</italic> gene function in PD, and mechanisms resulting from its mutation had not been elucidated. Given the same genetic location of the <italic>ZNF543</italic...

Topics

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• Cell Line
• Clustered Regularly Interspaced Short Palindromic Repeats
• CRISPR-Cas Systems
• Gene Editing
• Gene Expression Regulation
• Genetic Predisposition to Disease
• Mutation
• Parkinson Disease

Identifiers and source

Literature Corpus work

07ccf56f-2c0e-5de1-b94f-24b246adf699

DOI

10.21203/rs.3.rs-797710/v1