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Article

Layer-specific Nos3 expression and genotypic distribution in bicuspid aortic valve aortopathy.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery - 4 Oct 2022

Hill Jennifer C, Billaud Marie, Richards Tara D, Kotlarczyk Mary P, Shiva Sruti, Phillippi Julie A, Gleason Thomas G

Abstract excerpt

OBJECTIVES: We hypothesized that expression and activity of nitric oxide synthase-3 enzyme (Nos3) in bicuspid aortic valve (BAV) aortopathy are related to tissue layer and Nos3 genotype. METHODS: Gene expression of Nos3 and platelet and endothelial cell adhesion molecule-1 (Pecam1) and NOS activity were measured in intima-containing media and adventitial specimens of ascending aortic tissue. The presence of 2...

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Identifiers

PMID: 35460403
DOI: 10.1093/ejcts/ezac237
PMCID: PMC9615433

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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