Article
Selective ferroptosis vulnerability due to familial Alzheimer's disease presenilin mutations.
Cell death and differentiation - 1 Nov 2022
Greenough Mark A, Lane Darius J R, Balez Rachelle, Anastacio Helena Targa Dias, Zeng Zhiwen, Ganio Katherine, McDevitt Christopher A, Acevedo Karla, Belaidi Abdel Ali, Koistinaho Jari, Ooi Lezanne, Ayton Scott, Bush Ashley I
Abstract excerpt
Mutations in presenilin 1 and 2 (PS1 and PS2) cause autosomal dominant familial Alzheimer's disease (FAD). Ferroptosis has been implicated as a mechanism of neurodegeneration in AD since neocortical iron burden predicts Alzheimer's disease (AD) progression. We found that loss of the presenilins dramatically sensitizes multiple cell types to ferroptosis, but not apoptosis. FAD causal mutations of presenilins...
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