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Article

Genetic variation in the hypothalamic-pituitary-adrenal stress axis influences susceptibility to musculoskeletal pain: results from the EPIFUND study.

Annals of the rheumatic diseases - 1 Mar 2010

Holliday Kate L, Nicholl Barbara I, Macfarlane Gary J, Thomson Wendy, Davies Kelly A, McBeth John

Abstract excerpt

OBJECTIVES: To determine if genetic variation in genes in the hypothalamic-pituitary-adrenal (HPA) axis, the primary stress response system, influences susceptibility to developing musculoskeletal pain. METHODS: Pain and comorbidity data was collected at three time points in a prospective population-based cohort study. Pairwise tagging single nucleotide polymorphisms (SNPs) were selected and genotyped for seven...

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Source

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Identifiers

PMID: 19723618
DOI: 10.1136/ard.2009.116137
PMCID: PMC2927682

Genes

SERPINA6
CRHBP
POMC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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