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Article

Genetic causal effects of multi-site chronic pain on post-traumatic stress disorder: Evidence from a two-sample, two-step Mendelian randomization study.

Progress in neuro-psychopharmacology & biological psychiatry - 2 Apr 2025

Wang Zuxing, Lu Qiao, Hou Shuyu, Zhu Hongru

Abstract excerpt

BACKGROUND: Existing evidence supports a correlation between multi-site chronic pain and post-traumatic stress disorder (PTSD), but it is yet to be determined if this correlation is causal and in what direction the causation works. METHODS: Applying two-sample Mendelian randomization (MR) analysis to data from available genome-wide association studies in populations of European ancestry, we estimated the causal...

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PMID: 40044071
DOI: 10.1016/j.pnpbp.2025.111307

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