The genetic elucidation of monogenic obesity in the Arab world: a systematic review.

Abstract excerpt

BACKGROUND: Investigation of monogenic obesity (MO), a rare condition caused by a single gene variant(s), especially in consanguineous populations, is a powerful approach for obtaining novel insights into the genetic alterations involved. Here, we present a systematic review of the genetics of MO in the 22 Arab countries and apply protein modeling in silico to the missense variants reported. METHODS: We searched...

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