Article
How natural selection shapes genetic differentiation in the MHC region: A case study with Native Americans.
Human immunology - 1 Jul 2021
Nunes Kelly, Maia Maria Helena Thomaz, Dos Santos Eduardo José Melo, Dos Santos Sidney Emanuel Batista, Guerreiro João Farias, Petzl-Erler Maria Luiza, Bedoya Gabriel, Gallo Carla, Poletti Giovanni, Llop Elena, Tsuneto Luiza, Bortolini Maria Cátira, Rothhammer Francisco, Single Richard, Ruiz-Linares Andrés, Rocha Jorge, Meyer Diogo
Abstract excerpt
The Human Leukocyte Antigen (HLA) loci are extremely well documented targets of balancing selection, yet few studies have explored how selection affects population differentiation at these loci. In the present study we investigate genetic differentiation at HLA genes by comparing differentiation at microsatellites distributed genomewide to those in the MHC region. Our study uses a sample of 494 individuals from...
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