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SARS-CoV-2 infection relaxes peripheral B cell tolerance

14 Apr 2022

Abstract excerpt

Severe SARS-CoV-2 infection is associated with strong inflammation and autoantibody production against diverse self-antigens, suggesting a system-wide defect in B cell tolerance. BND cells are a B cell subset in healthy individuals harboring autoreactive but anergic B lymphocytes. In vitro evidence suggests inflammatory stimuli can breach peripheral B cell tolerance in this subset. We asked whether...

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PMID: 35420627
DOI: 10.1084/jem.20212553

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