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Article

CHD7 regulates bone-fat balance by suppressing PPAR-γ signaling

13 Apr 2022

Abstract excerpt

Chromodomain helicase DNA-binding protein 7 (CHD7), an ATP-dependent eukaryotic chromatin remodeling enzyme, is essential for the development of organs. The mutation of CHD7 is the main cause of CHARGE syndrome, but its function and mechanism in skeletal system remain unclear. Here, we show conditional knockout of Chd7 in bone marrow mesenchymal stem cells (MSCs) and preosteoblasts leads to a pathological...

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PMID: 35418650
DOI: 10.1038/s41467-022-29633-6

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