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Article

Precise genotyping of circular mobile elements from metagenomic data uncovers human-associated plasmids with recent common ancestors.

Genome research - 1 May 2022

Shalon Nitan, Relman David A, Yaffe Eitan

Abstract excerpt

Mobile genetic elements with circular genomes play a key role in the evolution of microbial communities. Their circular genomes correspond to circular walks in metagenome graphs, and yet, assemblies derived from natural microbial communities produce graphs riddled with spurious cycles, complicating the accurate reconstruction of circular genomes. We present DomCycle, an algorithm that reconstructs likely circular...

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Identifiers

PMID: 35414589
DOI: 10.1101/gr.275894.121
PMCID: PMC9104695

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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