Article
Common breast cancer susceptibility variants in LSP1 and RAD51L1 are associated with mammographic density measures that predict breast cancer risk.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jul 2012
Vachon Celine M, Scott Christopher G, Fasching Peter A, Hall Per, Tamimi Rulla M, Li Jingmei, Stone Jennifer, Apicella Carmel, Odefrey Fabrice, Gierach Gretchen L, Jud Sebastian M, Heusinger Katharina, Beckmann Matthias W, Pollan Marina, Fernández-Navarro Pablo, Gonzalez-Neira Anna, Benitez Javier, van Gils Carla H, Lokate Mariëtte, Onland-Moret N Charlotte, Peeters Petra H M, Brown Judith, Leyland Jean, Varghese Jajini S, Easton Douglas F, Thompson Deborah J, Luben Robert N, Warren Ruth M L, Wareham Nicholas J, Loos Ruth J F, Khaw Kay-Tee, Ursin Giske, Lee Eunjung, Gayther Simon A, Ramus Susan J, Eeles Rosalind A, Leach Martin O, Kwan-Lim Gek, Couch Fergus J, Giles Graham G, Baglietto Laura, Krishnan Kavitha, Southey Melissa C, Le Marchand Loic, Kolonel Laurence N, Woolcott Christy, Maskarinec Gertraud, Haiman Christopher A, Walker Kate, Johnson Nichola, McCormack Valeria A, Biong Margarethe, Alnaes Grethe I G, Gram Inger Torhild, Kristensen Vessela N, Børresen-Dale Anne-Lise, Lindström Sara, Hankinson Susan E, Hunter David J, Andrulis Irene L, Knight Julia A, Boyd Norman F, Figuero Jonine D, Lissowska Jolanta, Wesolowska Ewa, Peplonska Beata, Bukowska Agnieszka, Reszka Edyta, Liu JianJun, Eriksson Louise, Czene Kamila, Audley Tina, Wu Anna H, Pankratz V Shane, Hopper John L, dos-Santos-Silva Isabel
Abstract excerpt
BACKGROUND: Mammographic density adjusted for age and body mass index (BMI) is a heritable marker of breast cancer susceptibility. Little is known about the biologic mechanisms underlying the association between mammographic density and breast cancer risk. We examined whether common low-penetrance breast cancer susceptibility variants contribute to interindividual differences in mammographic density measures....
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