Article
Recurrent WWTR1 S89W mutations and Hippo pathway deregulation in clear cell carcinomas of the cervix.
The Journal of pathology - 1 Aug 2022
Kim Sarah H, Basili Thais, Dopeso Higinio, Da Cruz Paula Arnaud, Bi Rui, Issa Bhaloo Shirin, Pareja Fresia, Li Qing, da Silva Edaise M, Zhu Yingjie, Hoang Timothy, Selenica Pier, Murali Rajmohan, Chan Eric, Wu Michelle, Derakhshan Fatemeh, Maroldi Ana, Hanlon Etta, Ferreira Carlos Gil, Lapa E Silva Jose Roberto, Abu-Rustum Nadeem R, Zamarin Dmitriy, Chandarlapaty Sarat, Matrai Cathleen, Yoon Ju-Yoon, Reis-Filho Jorge S, Park Kay J, Weigelt Britta
Abstract excerpt
Clear cell carcinoma (CCC) of the cervix (cCCC) is a rare and aggressive type of human papillomavirus (HPV)-negative cervical cancer with limited effective treatment options for recurrent or metastatic disease. Historically, CCCs of the lower genital tract were associated with in utero diethylstilbestrol exposure; however, the genetic landscape of sporadic cCCCs remains unknown. Here we sought to define the...
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