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Article

FBXO32 targets PHPT1 for ubiquitination to regulate the growth of EGFR mutant lung cancer.

Cellular oncology (Dordrecht, Netherlands) - 1 Apr 2022

Zhang Ning, Liao Yifeng, Lv Weize, Zhu Shunda, Qiu Yeqing, Chen Nan, Xiao Mei, Zhang Hongyu

Abstract excerpt

BACKGROUND: Phosphohistidine phosphatase 1 (PHPT1) is an oncogene that has been reported to participate in multiple tumorigenic processes. As yet, however, the role of PHPT1 in lung cancer development remains uncharacterized. METHODS: RNA sequencing assay and 18 pairs of tumor and normal tissues from patients were analyzed to reveal the upregulation of PHPT1 in lung cancer, followed by confirming the biological...

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Source

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Identifiers

PMID: 35411430
DOI: 10.1007/s13402-022-00669-6
PMCID: PMC12978113

Genes

PHPT1
EGFR
FBXO32

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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