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Article

ZNF251 promotes the progression of lung cancer by activating ERK signaling.

Cancer science - 1 Sept 2020

Zhong Chenxi, Chen Chunji, Yao Feng, Fang Wentao

Abstract excerpt

Aberrant activation of ERK signaling is a hallmark of lung cancer. Although constitutively activating mutations of EGFR and KRAS contribute to the hyperactivation of ERK1/2, other mechanisms remain elusive. In this study, the zinc finger protein ZNF251 was found to be upregulated in clinical lung cancer samples, and it promoted the growth of lung cancer cells and the growth of primary lung KPC cells from mouse...

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Identifiers

PMID: 32589309
DOI: 10.1111/cas.14547
PMCID: PMC7469813

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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