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Article

TMF suppresses chondrocyte hypertrophy in osteoarthritic cartilage by mediating the FOXO3a/BMPER pathway

15 May 2024

Abstract excerpt

Osteoarthritis (OA) is a disease of the joints, characterized by chronic inflammation, cartilage destruction and extracellular matrix (ECM) remodeling. Aberrant chondrocyte hypertrophy promotes cartilage destruction and OA development. Collagen X, the biomarker of chondrocyte hypertrophy, is upregulated by runt‑related transcription factor 2 (Runx2), which is mediated by the bone morphogenetic protein 4...

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PMID: 38800044
DOI: 10.3892/etm.2024.12571

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