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Article

Quantitative peptidomics of Purkinje cell degeneration mice.

PloS one - 1 Jan 2013

Berezniuk Iryna, Sironi Juan J, Wardman Jonathan, Pasek Raymond C, Berbari Nicolas F, Yoder Bradley K, Fricker Lloyd D

Abstract excerpt

Cytosolic carboxypeptidase 1 (CCP1) is a metallopeptidase that removes C-terminal and side-chain glutamates from tubulin. The Purkinje cell degeneration (pcd) mouse lacks CCP1 due to a mutation. Previously, elevated levels of peptides derived from cytosolic and mitochondrial proteins were found in adult pcd mouse brain, raising the possibility that CCP1 functions in the degradation of intracellular peptides. To...

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Identifiers

PMID: 23593366
DOI: 10.1371/journal.pone.0060981
PMCID: PMC3620535

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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