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Philadelphia chromosome-negative myeloproliferative neoplasms: clinical aspects and treatment options.

International journal of hematology - 1 May 2022

Gotoh Akihiko

Abstract excerpt

Clinical studies of Philadelphia chromosome-negative myeloproliferative neoplasms (MPN) have progressed greatly with the discovery of mutations in three driver genes: JAK2, MPL, and calreticulin. Other genes that may play important roles in pathogenesis and progression of MPN have also been identified. Several prognostic prediction systems based on various risk factors including these genetic factors have been...

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PMID: 35397744
DOI: 10.1007/s12185-022-03344-6

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