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Article

Targeting Abnormal Hematopoietic Stem Cells in Chronic Myeloid Leukemia and Philadelphia Chromosome-Negative Classical Myeloproliferative Neoplasms.

International journal of molecular sciences - 11 Jan 2021

Yung Yammy, Lee Emily, Chu Hiu-Tung, Yip Pui-Kwan, Gill Harinder

Abstract excerpt

Myeloproliferative neoplasms (MPNs) are unique hematopoietic stem cell disorders sharing mutations that constitutively activate the signal-transduction pathways involved in haematopoiesis. They are characterized by stem cell-derived clonal myeloproliferation. The key MPNs comprise chronic myeloid leukemia (CML), polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). CML is...

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Identifiers

PMID: 33440869
DOI: 10.3390/ijms22020659
PMCID: PMC7827471

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