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Article

Targeting PDGFRA-SHP2 signaling enhances radiotherapy in IDH1-mutant glioma.

Neuro-oncology - 17 Sept 2025

Yu Xiaozhou, Song Xiao, Tiek Deanna, Wu Runxin, Walker Maya, Horbinski Craig, Hu Bo, Cheng Shi-Yuan

Abstract excerpt

BACKGROUND: Isocitrate dehydrogenase mutant (IDH-mut) gliomas represent a distinct subtype of glioma, characterized by a relatively better prognosis compared to IDH wildtype (wt) glioblastoma (GBM). Despite this advantage, these tumors remain incurable due to the limited availability of effective treatments. Targeting SHP2, a non-receptor protein tyrosine phosphatase, is a promising therapeutic strategy for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40128633
DOI: 10.1093/neuonc/noaf086
PMCID: PMC12448894

Genes

PDGFRA
GSC
IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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