Article
Somatic NRAS mutation in patient with generalized lymphatic anomaly.
Angiogenesis - 1 May 2018
Manevitz-Mendelson Eugenia, Leichner Gil S, Barel Ortal, Davidi-Avrahami Inbal, Ziv-Strasser Limor, Eyal Eran, Pessach Itai, Rimon Uri, Barzilai Aviv, Hirshberg Abraham, Chechekes Keren, Amariglio Ninette, Rechavi Gideon, Yaniv Karina, Greenberger Shoshana
Abstract excerpt
Generalized lymphatic anomaly (GLA or lymphangiomatosis) is a rare disease characterized by a diffuse proliferation of lymphatic vessels in skin and internal organs. It often leads to progressive respiratory failure and death, but its etiology is unknown. Here, we isolated lymphangiomatosis endothelial cells from GLA tissue. These cells were characterized by high proliferation and survival rates, but displayed...
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