Article
Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes.
Nature - 22 Feb 2012
Molenaar Jan J, Koster Jan, Zwijnenburg Danny A, van Sluis Peter, Valentijn Linda J, van der Ploeg Ida, Hamdi Mohamed, van Nes Johan, Westerman Bart A, van Arkel Jennemiek, Ebus Marli E, Haneveld Franciska, Lakeman Arjan, Schild Linda, Molenaar Piet, Stroeken Peter, van Noesel Max M, Ora Ingrid, Santo Evan E, Caron Huib N, Westerhout Ellen M, Versteeg Rogier
Abstract excerpt
Neuroblastoma is a childhood tumour of the peripheral sympathetic nervous system. The pathogenesis has for a long time been quite enigmatic, as only very few gene defects were identified in this often lethal tumour. Frequently detected gene alterations are limited to MYCN amplification (20%) and ALK activations (7%). Here we present a whole-genome sequence analysis of 87 neuroblastoma of all stages. Few recurrent...
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