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Comprehensive profiling of myxopapillary ependymomas identifies a distinct molecular subtype with relapsing disease

5 Apr 2022

Abstract excerpt

BACKGROUND: Myxopapillary ependymoma (MPE) is a heterogeneous disease regarding histopathology and outcome. The underlying molecular biology is poorly understood, and markers that reliably predict the patients' clinical course are unknown. METHODS: We assembled a cohort of 185 tumors classified as MPE based on DNA methylation. Methylation patterns, copy number profiles, and MGMT promoter methylation were analyzed...

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PMID: 35380708
DOI: 10.1093/neuonc/noac088

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