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Article

Multiplatform Molecular Profiling Reveals Epigenomic Intratumor Heterogeneity in Ependymoma.

Cell reports - 4 Feb 2020

Liu S John, Magill Stephen T, Vasudevan Harish N, Hilz Stephanie, Villanueva-Meyer Javier E, Lastella Sydney, Daggubati Vikas, Spatz Jordan, Choudhury Abrar, Orr Brent A, Demaree Benjamin, Seo Kyounghee, Ferris Sean P, Abate Adam R, Oberheim Bush Nancy Ann, Bollen Andrew W, McDermott Michael W, Costello Joseph F, Raleigh David R

Abstract excerpt

Ependymomas exist within distinct genetic subgroups, but the molecular diversity within individual ependymomas is unknown. We perform multiplatform molecular profiling of 6 spatially distinct samples from an ependymoma with C11orf95-RELA fusion. DNA methylation and RNA sequencing distinguish clusters of samples according to neuronal development gene expression programs that could also be delineated by differences...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32023450
DOI: 10.1016/j.celrep.2020.01.018
PMCID: PMC7313374

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