Article
Transcriptomic and epigenetic dissection of spinal ependymoma (SP-EPN) identifies clinically relevant subtypes enriched for tumors with and without NF2 mutation.
Acta neuropathologica - 24 Jan 2024
Neyazi Sina, Yamazawa Erika, Hack Karoline, Tanaka Shota, Nagae Genta, Kresbach Catena, Umeda Takayoshi, Eckhardt Alicia, Tatsuno Kenji, Pohl Lara, Hana Taijun, Bockmayr Michael, Kim Phyo, Dorostkar Mario M, Takami Toshihiro, Obrecht Denise, Takai Keisuke, Suwala Abigail K, Komori Takashi, Godbole Shweta, Wefers Annika K, Otani Ryohei, Neumann Julia E, Higuchi Fumi, Schweizer Leonille, Nakanishi Yuta, Monoranu Camelia-Maria, Takami Hirokazu, Engertsberger Lara, Yamada Keisuke, Ruf Viktoria, Nomura Masashi, Mohme Theresa, Mukasa Akitake, Herms Jochen, Takayanagi Shunsaku, Mynarek Martin, Matsuura Reiko, Lamszus Katrin, Ishii Kazuhiko, Kluwe Lan, Imai Hideaki, von Deimling Andreas, Koike Tsukasa, Benesch Martin, Kushihara Yoshihiro, Snuderl Matija, Nambu Shohei, Frank Stephan, Omura Takaki, Hagel Christian, Kugasawa Kazuha, Mautner Viktor F, Ichimura Koichi, Rutkowski Stefan, Aburatani Hiroyuki, Saito Nobuhito, Schüller Ulrich
Abstract excerpt
Ependymomas encompass multiple clinically relevant tumor types based on localization and molecular profiles. Tumors of the methylation class "spinal ependymoma" (SP-EPN) represent the most common intramedullary neoplasms in children and adults. However, their developmental origin is ill-defined, molecular data are scarce, and the potential heterogeneity within SP-EPN remains unexplored. The only known recurrent...
Topics
- Adult
- Child
- Humans
- Transcriptome