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Article

Germline mutations in the alternative pathway of complement predispose to HELLP syndrome.

JCI insight - 22 Mar 2018

Vaught Arthur J, Braunstein Evan M, Jasem Jagar, Yuan Xuan, Makhlin Igor, Eloundou Solange, Baines Andrea C, Merrill Samuel A, Chaturvedi Shruti, Blakemore Karin, Sperati C John, Brodsky Robert A

Abstract excerpt

BACKGROUND: HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome is a severe variant of hypertensive disorders of pregnancy affecting approximately 1% of all pregnancies, and has significant maternal and fetal morbidity. Previously, we showed that upregulation of the alternative pathway of complement (APC) plays a role in HELLP syndrome. We hypothesize that HELLP syndrome follows a 2-hit disease...

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Identifiers

PMID: 29563339
DOI: 10.1172/jci.insight.99128
PMCID: PMC5926944

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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