Article
HLA-A68 and HLA-B15 alleles correlate with poor immune response among AIDS patients on combined antiretroviral therapy.
Human immunology - 1 Jun 2016
El-Beeli Marah, Al-Mahrooqi Samira Hamad, Youssef Randa Mahmoud, Zadjali Fahad, Balkhair Abdullah, Al-Balushi Mohammed Said, Said Elias Anthony, Hasson Sidgi Syed, Al-Jabri Ali Abdullah
Abstract excerpt
Around 15-30% of AIDS patients fail to recover their CD4(+) T cell levels following combined antiretroviral therapy despite successful inhibition of HIV-1 replication. The exact reasons for this immune recovery failure are not completely understood. HLA alleles are among the candidate that may explain this failure. A total of 65 adult AIDS patients, with viral load of <50 copies per ml were investigated. Viral...
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