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Sexually dimorphic DNA methylation and gene expression patterns in human first trimester placenta

16 Aug 2024

Abstract excerpt

BACKGROUND: Fetal sex and placental development impact pregnancy outcomes and fetal-maternal health, but the critical timepoint of placenta establishment in first trimester is understudied in human pregnancies. METHODS: Pregnant subjects were recruited in late first trimester (weeks 10-14) at time of chorionic villus sampling, a prenatal diagnostic test. Leftover placenta tissue was collected and stored until...

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PMID: 39152463
DOI: 10.1186/s13293-024-00629-9

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