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Newborn DNA-methylation, childhood lung function, and the risks of asthma and COPD across the life course

14 Feb 2019

Abstract excerpt

Rationale We aimed to identify differentially methylated regions (DMRs) in cord blood DNA associated with childhood lung function, asthma and chronic obstructive pulmonary disease (COPD) across the life course. Methods We meta-analysed epigenome-wide data of 1688 children from five cohorts to identify cord blood DMRs and their annotated genes, in relation to forced expiratory volume in 1 s (FEV1), FEV1/forced...

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PMID: 30765504
DOI: 10.1183/13993003.01795-2018

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