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Article

Scinderin promotes fusion of electron transport chain dysfunctional muscle stem cells with myofibers

27 Jan 2022

Abstract excerpt

Muscle stem cells (MuSCs) experience age-associated declines in number and function, accompanied by mitochondrial electron transport chain (ETC) dysfunction and increased reactive oxygen species (ROS). The source of these changes, and how MuSCs respond to mitochondrial dysfunction, is unknown. We report here that in response to mitochondrial ROS, murine MuSCs directly fuse with neighboring myofibers; this...

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PMID: 35342888
DOI: 10.1038/s43587-021-00164-x

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