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Article

Computational Analysis of the Potential Impact of MTC Complex Missenses SNPs Associated with Male Infertility.

BioMed research international - 1 Jan 2022

Harmak Houda, Charoute Hicham, Redouane Salaheddine, Filali Ouafaa Aniq, Barakat Abdelhamid, Rouba Hassan

Abstract excerpt

Meiotic chromosomes endure rapid prophase movements that ease the formation of interhomologue recombination intermediates that drive synapsis, crossing over, and segregation process. To generate these fast moves, the meiotic telomere complex (MTC) enables telomere-inner nuclear membrane attachment during meiotic prophase I and transfers cytoskeletal signals via another complex: the LINC complex. Furthermore,...

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Identifiers

PMID: 35342767
DOI: 10.1155/2022/1664825
PMCID: PMC8956405

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