Article
Synthesis of 2H-Imidazo[2',1':2,3] [1,3]thiazolo[4,5-e]isoindol-8-yl-phenylureas with promising therapeutic features for the treatment of acute myeloid leukemia (AML) with FLT3/ITD mutations.
European journal of medicinal chemistry - 5 May 2022
Cilibrasi Vincenzo, Spanò Virginia, Bortolozzi Roberta, Barreca Marilia, Raimondi Maria Valeria, Rocca Roberta, Maruca Annalisa, Montalbano Alessandra, Alcaro Stefano, Ronca Roberto, Viola Giampietro, Barraja Paola
Abstract excerpt
Despite progressive advances in understanding the molecular biology of acute myeloid leukemia (AML), the conventional therapeutic approach has not changed substantially, and the outcome for most patients is poor. Thus, continuous efforts on the discovery of new compounds with improved features are required. Following a multistep sequence, we have identified a new tetracyclic ring system with strong...
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