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Article

Development and bio-evaluation of novel indolizine derivatives in FLT3 mutant acute myeloid leukemia cells.

Bioorganic & medicinal chemistry letters - 1 Jan 2026

Xing Qianlu, Li Jiangdong, Shen Yanjiao, He Lu, Ma Xiaojuan, Huang Pei, Huang Qiang, Chen Yan

Abstract excerpt

Acute myeloid leukemia (AML) is a highly malignant blood tumor, and FLT3 serves as an important molecular target for the treatment of AML. Currently, FLT3 inhibitors still have issues of drug resistance and unsatisfactory clinical efficacy in the treatment of AML. Indolizine derivatives exhibit good antibacterial and antitumor biological activities. Based on the synthesis and identification of a library of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41052609
DOI: 10.1016/j.bmcl.2025.130429

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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