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Design and synthesis 1H-Pyrrolo[2,3-b]pyridine derivatives as FLT3 inhibitors for the treatment of Acute myeloid Leukemia.

Bioorganic & medicinal chemistry - 15 Feb 2024

Wei Tian-Hua, Zhou Yun, Yang Jin, Zhang Meng-Yuan, Wang Jing-Jing, Tong Zhen-Jiang, Wu Jia-Zhen, Wang Yi-Bo, Sha Jiu-Kai, Chen Min, Ding Ning, Yu Yan-Cheng, Dai Wei-Chen, Leng Xue-Jiao, Xue Xin, Sun Shan-Liang, Wang Xiao-Long, Li Nian-Guang, Shi Zhi-Hao

Abstract excerpt

Acute myeloid leukemia (AML) is the most common type of blood cancer and has been strongly correlated with the overexpression of Fms-like tyrosine kinase 3 (FLT3), a member of the class III receptor tyrosine kinase family. With the emergence of FLT3 internal tandem duplication alteration (ITD) and tyrosine kinase domain (TKD) mutations, the development of FLT3 small molecule inhibitors has become an effective...

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Identifiers

PMID: 38330848
DOI: 10.1016/j.bmc.2024.117631

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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