Inhibition of FLT3-ITD Kinase in Acute Myeloid Leukemia by New Imidazo[1,2-b]pyridazine Derivatives Identified by Scaffold Hopping.

doi:10.1021/acs.jmedchem.3c00575

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Article

Inhibition of FLT3-ITD Kinase in Acute Myeloid Leukemia by New Imidazo[1,2-b]pyridazine Derivatives Identified by Scaffold Hopping.

Journal of medicinal chemistry - 24 Aug 2023

Břehová Petra, Řezníčková Eva, Škach Kryštof, Jorda Radek, Dejmek Milan, Vojáčková Veronika, Šála Michal, Kovalová Markéta, Dračínský Martin, Dolníková Alexandra, Strmeň Timotej, Kinnertová Monika, Chalupský Karel, Dvořáková Alexandra, Gucký Tomáš, Mertlíková Kaiserová Helena, Klener Pavel, Nencka Radim, Kryštof Vladimír

Abstract excerpt

FLT3 kinase is a potential drug target in acute myeloid leukemia (AML). Patients with FLT3 mutations typically have higher relapse rates and worse outcomes than patients without FLT3 mutations. In this study, we investigated the suitability of various heterocycles as central cores of FLT3 inhibitors, including thieno[3,2-d]pyrimidine, pyrazolo[1,5-a]pyrimidine, imidazo[4,5-b]pyridine, pyrido[4,3-d]pyrimidine, and...

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PMID: 37535845
DOI: 10.1021/acs.jmedchem.3c00575
PMCID: PMC10461230

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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