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Article

Discovery of Oxazol-2-amine Derivatives as Potent Novel FLT3 Inhibitors.

Molecules (Basel, Switzerland) - 5 Nov 2020

Kim Hyo Jeong, Ryu Hwani, Song Jie-Young, Hwang Sang-Gu, Jalde Shivakumar S, Choi Hyun-Kyung, Ahn Jiyeon

Abstract excerpt

Internal tandem duplication (ITD) of FMS-like tyrosine kinase 3 (FLT3) is the most common mutation in patients with acute myeloid leukemia (AML). FLT3-ITD+ induces constitutive activation of FLT3, causing an abnormally rapid proliferation of cancer cells. In this study, we identified novel FLT3 inhibitors and investigated 5-(4-fluorophenyl)-N-phenyloxazol-2-amine (compound 7; 7c) as candidates for the treatment...

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PMID: 33167505
DOI: 10.3390/molecules25215154
PMCID: PMC7663913

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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