MERS-CoV ORF4b employs an unusual binding mechanism to target IMPα and block innate immunity

Abstract excerpt

The MERS coronavirus (MERS-CoV) is a highly pathogenic, emerging virus that produces accessory proteins to antagonize the host innate immune response. The MERS-CoV ORF4b protein has been shown to bind preferentially to the nuclear import adapter IMPα3 in infected cells, thereby inhibiting NF-κB-dependent innate immune responses. Here, we report high-resolution structures of ORF4b bound to two distinct IMPα family...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to interferon and immune responses
• Share to RNA modifications and cancer
• Share to Viral gastroenteritis research and epidemiology