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Antibodies Targeting KSHV gH/gL Reveal Distinct Neutralization Mechanisms

5 Mar 2022

Abstract excerpt

Kaposi's sarcoma herpesvirus (KSHV) is associated with a significant disease burden, in particular in Sub-Sahara Africa. A KSHV vaccine would be highly desirable, but the mechanisms underlying neutralizing antibody responses against KSHV remain largely unexplored. The complex made of glycoproteins H and L (gH/gL) activates gB for the fusion of viral and cellular membranes in all herpesviruses. KSHV gH/gL also...

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PMID: 35336948
DOI: 10.3390/v14030541

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