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Article

Polymorphisms in the hypoxia inducible factor binding site of the macrophage migration inhibitory factor gene promoter in schizophrenia.

PloS one - 1 Jan 2022

Okazaki Satoshi, Boku Shuken, Watanabe Yuichiro, Otsuka Ikuo, Horai Tadasu, Morikawa Ryo, Kimura Atsushi, Shimmyo Naofumi, Tanifuji Takaki, Someya Toshiyuki, Hishimoto Akitoyo

Abstract excerpt

BACKGROUND: Macrophage migration inhibitory factor (MIF) is a multifunctional cytokine that promotes neurogenesis and neuroprotection. MIF is predominantly expressed in astrocytes in the brain. The serum MIF level and microsatellites/single nucleotide polymorphisms (SNPs) in the MIF gene promoter region are known to be associated with schizophrenia (SCZ). Interestingly, previous studies reported that hypoxia, an...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35324982
DOI: 10.1371/journal.pone.0265738
PMCID: PMC8946738

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