Article
Association study of a single nucleotide polymorphism in the hypoxia response element of the macrophage migration inhibitory factor gene promoter with suicide completers in the Japanese population.
Neuropsychopharmacology reports - 1 Mar 2024
Shirai Toshiyuki, Okazaki Satoshi, Tanifuji Takaki, Otsuka Ikuo, Miyachi Masao, Okada Shohei, Shindo Ryota, Horai Tadasu, Mouri Kentaro, Takahashi Motonori, Kondo Takeshi, Ueno Yasuhiro, Hishimoto Akitoyo
Abstract excerpt
BACKGROUND: More than 800 000 people die by suicide annually. The heritability of suicide is 30%-50%. We focused on the hypoxia response element (HRE), which promotes the expression of macrophage migration inhibitory factor (MIF) via the hypoxia-inducible factor (HIF) pathway, important in neurogenesis and neuroprotection. We examined a genetic polymorphism of rs17004038, a single-nucleotide polymorphism (SNP),...
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