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Expanding the therapeutic potential of neuro(active)steroids: a promising strategy for hyperdopaminergic behavioral phenotypes.

Neuroscience and biobehavioral reviews - 1 Sept 2024

Scheggi Simona, Concas Luca, Corsi Sara, Carta Manolo, Melis Miriam, Frau Roberto

Abstract excerpt

Imbalances in dopamine activity significantly contribute to the pathophysiology of several neuropsychiatric disorders, including addiction, ADHD, schizophrenia, impulse control disorders, and Parkinson's Disease. Neuro(active)steroids, comprising endogenous steroids that finely modulate neuronal activity, are considered crucial regulators of brain function and behavior, with implications in various physiological...

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PMID: 39103066
DOI: 10.1016/j.neubiorev.2024.105842

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