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Risk of Peritoneal Carcinomatosis After Risk-Reducing Salpingo-Oophorectomy: A Systematic Review and Individual Patient Data Meta-Analysis.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Jun 2022

Steenbeek Miranda P, van Bommel Majke H D, Bulten Johan, Hulsmann Julia A, Bogaerts Joep, Garcia Christine, Cun Han T, Lu Karen H, van Beekhuizen Heleen J, Minig Lucas, Gaarenstroom Katja N, Nobbenhuis Marielle, Krajc Mateja, Rudaitis Vilius, Norquist Barbara M, Swisher Elizabeth M, Mourits Marian J E, Massuger Leon F A G, Hoogerbrugge Nicoline, Hermens Rosella P M G, IntHout Joanna, de Hullu Joanne A

Abstract excerpt

PURPOSE: After risk-reducing salpingo-oophorectomy (RRSO), BRCA1/2 pathogenic variant (PV) carriers have a residual risk to develop peritoneal carcinomatosis (PC). The etiology of PC is not yet clarified, but may be related to serous tubal intraepithelial carcinoma (STIC), the postulated origin for high-grade serous cancer. In this systematic review and individual patient data meta-analysis, we investigate the...

Topics

Breast Neoplasms
Cystadenocarcinoma, Serous
Fallopian Tube Neoplasms
Female
Heterozygote
Humans
Mutation
Ovarian Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ovariectomy

Peritoneal Neoplasms

Salpingo-oophorectomy

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Identifiers

PMID: 35302882
DOI: 10.1200/JCO.21.02016
PMCID: PMC9851686

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Risk of Peritoneal Carcinomatosis After Risk-Reducing Salpingo-Oophorectomy: A Systematic Review and Individual Patient Data Meta-Analysis.PMID 35302882Read ↗

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Early diagnosis of peritoneal carcinoma based on a subtle rise in serum CA125 level within the normal range in a BRCA2 mutation carrier with serous tubal intraepithelial carcinoma discovered after risk-reducing salpingo-oophorectomy: A case report and literature review.Semantic proximity Read ↗

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