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CRISPR Modeling and Correction of Cardiovascular Disease

9 Jun 2022

Abstract excerpt

Cardiovascular disease remains the leading cause of morbidity and mortality in the developed world. In recent decades, extraordinary effort has been devoted to defining the molecular and pathophysiological characteristics of the diseased heart and vasculature. Mouse models have been especially powerful in illuminating the complex signaling pathways, genetic and epigenetic regulatory circuits, and multicellular...

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PMID: 35679361
DOI: 10.1161/circresaha.122.320496

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