Article
Single Mutation on Trastuzumab Modulates the Stability of Antibody-Drug Conjugates Built Using Acetal-Based Linkers and Thiol-Maleimide Chemistry.
Journal of the American Chemical Society - 30 Mar 2022
Ferhati Xhenti, Jiménez-Moreno Ester, Hoyt Emily A, Salluce Giulia, Cabeza-Cabrerizo Mar, Navo Claudio D, Compañón Ismael, Akkapeddi Padma, Matos Maria J, Salaverri Noelia, Garrido Pablo, Martínez Alfredo, Laserna Víctor, Murray Thomas V, Jiménez-Osés Gonzalo, Ravn Peter, Bernardes Gonçalo J L, Corzana Francisco
Abstract excerpt
Antibody-drug conjugates (ADCs) are a class of targeted therapeutics used to selectively kill cancer cells. It is important that they remain intact in the bloodstream and release their payload in the target cancer cell for maximum efficacy and minimum toxicity. The development of effective ADCs requires the study of factors that can alter the stability of these therapeutics at the atomic level. Here, we present a...
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