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Methylenetetrahydrofolate Reductase Gene rs1801133 and rs1801131 Polymorphisms and Essential Hypertension Risk: A Comprehensive Analysis.

Cardiovascular therapeutics - 1 Jan 2022

Fan Yingchao, Wu Liting, Zhuang Wenfang

Abstract excerpt

Background: Essential hypertension (EH) is a common and multifactorial disorder that is likely to be influenced by multiple genes. The methylenetetrahydrofolate reductase (MTHFR) gene rs1801133 and rs1801131 polymorphisms influence MTHFR enzyme activity and plasma homocysteine concentration. In addition, variations in MTHFR functions likely play roles in the etiology of EH. Thus far, a large number of studies...

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PMID: 35284002
DOI: 10.1155/2022/2144443
PMCID: PMC8888071

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