Article
Association of single nucleotide polymorphisms of MTHFR, TCN2, RNF213 with susceptibility to hypertension and blood pressure.
Bioscience reports - 20 Dec 2019
Liu Shan, Liu Mengwei, Li Qian, Liu Xiuping, Wang Yue, Mambiya Michael, Zhang Kaili, Yang Luping, Zhang Qian, Shang Mengke, Zeng Fanxin, Nie Fangfang, Liu Wanyang
Abstract excerpt
Methylenetetrahydrofolate reductase gene (MTHFR), transcobalaminII (TCN2) and ring finger protein 213 (RNF213) are related to homocysteine (Hcy) level and are of great significance for hypertension. We aimed to evaluate the associations of MTHFR (rs1801133, rs1801131, rs9651118), TCN2 (rs117353193) and RNF213 (rs9916351) with hypertension and blood pressure (BP). A total of 953 patients with hypertension and 1103...