Article

Human genetic adaptation related to cellular zinc homeostasis

2022-07-01

Abstract excerpt

SLC30A9 encodes a ubiquitously zinc transporter (ZnT9) and has been consistently suggested as a candidate for positive selection in humans. However, no direct adaptive molecular phenotype has been demonstrated. Our results provide evidence for directional selection operating in two major complementary haplotypes in Africa and East Asia. These haplotypes are associated with differential gene expression but also dif...

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Literature Corpus work: c14ae1c2-c213-58ea-9b33-991509851121
DOI: 10.1101/2022.06.29.498106

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